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New England Journal of Medicine (NEJM) Audio Summaries Podcasts

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 10.

This summary covers the issue of September 4, 2008. Featured are articles on the quality of life with defibrillator therapy or amiodarone in heart failure, prognostic importance of defibrillator shocks in patients with heart failure, and hyponatremia and mortality among patients on the liver-transplant waiting list; review articles on hereditary angioedema and on the management of acute cutaneous wounds; a Clinical Problem-Solving article describing collateral damage; a Clinical Decisions ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 9.

This summary covers the issue of August 28, 2008. Featured are articles on magnesium sulfate for the prevention of cerebral palsy, bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma, brain-derived neurotrophic factor and obesity in the WAGR syndrome, and intraocular neovascularization and edema; review articles on the management of acute bleeding from a peptic ulcer and on mechanisms of thrombus formation; a case report of a man with abdominal pain, nausea, ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 8.

This summary covers the issue of August 21, 2008. Featured are articles on variants of SLCO1B1 associated with statin-induced myopathy, preeclampsia and the risk of end-stage renal disease, adalimumab with or without methotrexate in juvenile rheumatoid arthritis, and health and economic implications of HPV vaccination in the United States; a review article on idiopathic sudden sensorineural hearing loss; a case report of a woman with headache and behavioral changes; and Perspective article ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 7.

This summary covers the issue of August 14, 2008. Featured are articles on the effect of PCI on quality of life in patients with stable coronary disease, bivalirudin vs. unfractionated heparin during PCI, effects of tibolone in older postmenopausal women, pediatric heart transplantation after declaration of cardiocirculatory death, and harnessing the power of bacteria to protect the gut; review articles on naltrexone for the management of alcohol dependence and on chromosomal abnormalities ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 6.

This summary covers the issue of August 7, 2008. Featured are articles on extensively drug-resistant tuberculosis; monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia; fibroblast growth factor 23 and mortality among patients undergoing hemodialysis; HHV-6A in syncytial giant-cell hepatitis; and Medicare, graduate medical education, and new policy directions; review articles on malaria prevention during short-term travel and on monoclonal antibody therapy for B-cell non-Hodgkin ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 5.

This summary covers the issue of July 31, 2008. Featured are articles on D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer, lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission, effect of cyclosporine on reperfusion injury in acute myocardial infarction, smoke-free legislation and hospitalizations for acute coronary syndrome, tort liability for patient-caused accidents, and patching a leaky intestine; a review article ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 4.

This summary covers the issue of July 24, 2008. Featured are articles on raltegravir with optimized background therapy for resistant HIV infection, subgroup and resistance analyses of raltegravir for resistant HIV infection, detection of mutations in EGFR in circulating lung-cancer cells, and sorafenib in advanced hepatocellular carcinoma; a review article on hypoparathyroidism; a case report of a man with back pain and a mass in the lung; and Perspective articles on tier 4 drugs and the f ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 3.

This summary covers the issue of July 17, 2008. Featured are articles on weight loss with a low-carbohydrate, Mediterranean, or low-fat diet; rituximab and immune globulin in renal transplantation; effect of dissemination of evidence in reducing injuries from falls; long-term medical and social consequences of preterm birth; exclusion of patients from pay-for-performance targets; and the antiinflammatory IgG; a review article on acetylcysteine for acetaminophen poisoning; a case report of ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 2.

This summary covers the issue of July 10, 2008. Featured are articles on extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission; early, abrupt weaning and HIV-free survival of children in Zambia; noninvasive ventilation in acute cardiogenic pulmonary edema; familial myeloma; atrial natriuretic peptide frameshift mutation in familial atrial fibrillation; and wellness programs and lifestyle discrimination; a review article on the initial management of epilepsy; a case r ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 359, No. 1.

This summary covers the issue of July 3, 2008. Featured are articles on the intensity of renal support in critically ill patients, epinephrine with or without vasopressin in cardiopulmonary resuscitation, motesanib diphosphate in progressive differentiated thyroid cancer, endomyocardial fibrosis in Mozambique, adoption of electronic health records in ambulatory care, and removing the golden coat of Staphylococcus aureus; a review article on the effect of in utero and early-life conditions ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 358, No. 26.

This summary covers the issue of June 26, 2008. Featured are articles on rivaroxaban versus enoxaparin after hip arthroplasty; rivaroxaban versus enoxaparin after total knee arthroplasty; angiotensin II blockade and aortic-root dilation in Marfan's syndrome; polygenes, risk prediction, and targeted prevention of breast cancer; and solid-organ transplantation and donor risk factors; a review article on acute calculous cholecystitis; a case report of a woman with abdominal pain and weakness ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 358, No. 25.

This summary covers the issue of June 19, 2008. Featured are articles on rhythm control versus rate control for atrial fibrillation and heart failure, increased mortality after dronedarone therapy for severe heart failure, electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1, treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1, over-the-counter sales of drugs for asymptomatic conditions, and on tumor necrosis factor α and colitis- ...

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NEJM This Week: Supplement to the New England Journal of Medicine, Vol. 358, No. 24.

This summary covers the issue of June 12, 2008. Featured are articles on effects of intensive glucose lowering in type 2 diabetes, intensive blood glucose control and vascular outcomes in patients with type 2 diabetes, an H5N1 vaccine derived from cell culture, and a genetic susceptibility to neuroblastoma; review articles on Graves’ disease and on age-related macular degeneration; a case report of a man with headache and visual changes after liver transplantation; and Perspective ar ...

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NEJM This Week - Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 23.

This summary covers the issue of June 5, 2008. Featured are articles on aliskiren combined with losartan in type 2 diabetes and nephropathy, hypothermia therapy in children with traumatic brain injury, contaminated heparin and activation of the contact system, socioeconomic inequalities in health in European countries, and metabolism and therapeutic angiogenesis; a review article on chemotherapy-induced nausea and vomiting; a Clinical Problem-Solving article describing a joint venture; and ...

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NEJM This Week - Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 22.

This summary covers the issue of May 29, 2008. Featured are articles on aprotinin versus lysine analogues in high-risk cardiac surgery, methylnaltrexone for opioid-induced constipation in advanced illness, a placebo-controlled trial of prucalopride for severe chronic constipation, and multiple genetic loci for bone mineral density and fractures; review articles on precocious puberty and on the hepatopulmonary syndrome; a case report of a man with metastatic renal-cell carcinoma; and Perspe ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 21.

This summary covers the issue of May 22, 2008. Featured are articles on facilitated PCI in ST-elevation myocardial infarction, bivalirudin during PCI in acute myocardial infarction, gene therapy for Leber’s congenital amaurosis, the collective dynamics of smoking in a large social network, and how HIV guts the immune system; a review article on sublingual immunotherapy; a case report of a woman with bone pain; and Perspective articles on direct-to-consumer advertising of drug-eluting ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 20.

This summary covers the issue of May 15, 2008. Featured are articles on class-sparing regimens for initial treatment of HIV-1 infection, biomarkers to predict death from cardiovascular causes, cardiac troponin in acute heart failure, recombinant activated factor VII for intracerebral hemorrhage; review articles on rotator-cuff failure and on biomarkers in heart failure; a case report of a man with an elevated PSA level and early-stage prostate cancer; and Perspective articles on vaccines, ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 19.

This summary covers the issue of May 8, 2008. Featured are articles on hyperglycemia and adverse pregnancy outcomes, metformin plus insulin for the treatment of gestational diabetes, sudden cardiac arrest and early repolarization, left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia, an immunodeficiency disease with RAG mutations and granulomas, and targeting tumor angiogenesis; a review article on tumor angiogenesis; a case report of a man with an ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 18.

This summary covers the issue of May 1, 2008. Featured are articles on hypertension in the very elderly, the shared genetic causes of childhood-onset cardiac hypertrophy, gene mutations and outcomes in cytogenetically normal AML, microRNA expression in cytogenetically normal AML, and a behavioral intervention to improve obstetrical care; a review article on the nonsurgical management of obesity in adults; a Clinical Problem-Solving article entitled "Back to Basics"; and Perspective article ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 17.

This summary covers the issue of April 24, 2008. Featured are articles on stents versus coronary-artery bypass grafting for left main coronary artery disease, home AEDs for sudden cardiac arrest, pyruvate kinase deficiency and malaria, mutations in the iodotyrosine deiodinase gene and hypothyroidism, ezetimibe use in the United States and Canada, and mast cells and pancreatic cancer; a review article on artesunate for severe falciparum malaria; a case report of a man with rheumatoid arthri ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 16.

This summary covers the issue of April 17, 2008. Featured are articles on weekly paclitaxel and breast cancer, intensive care for extremely premature newborns, YKL-40 levels and asthma, pharmaceutical promotion to physicians and first amendment rights, tectonic shifts in the health information economy, electronic health records and medical research, and grassroots activism and physician supply; review articles on the irritable bowel syndrome and on the management of very low birth weight; ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 15.

This summary covers the issue of April 10, 2008. Featured are articles on telmisartan, ramipril, or both in high-risk vascular disease, acyclovir and the incidence of HIV infection among women in Tanzania, long-term results of carotid stenting versus endarterectomy, recent resurgence of mumps in the United States, legal and regulatory issues in medical outsourcing, and activated protein C and diabetic nephropathy; a review article on the challenge of HIV-1 subtype diversity; a case report ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 14.

This summary covers the issue of April 3, 2008. Featured are articles on simvastatin with or without ezetimibe in familial hypercholesterolemia, obesity and increased use of health care during pregnancy, a gene for the cblD defect of vitamin B12 metabolism, treatment of vulvar intraepithelial neoplasia with topical imiquimod, and options for slowing the growth of health care costs; review articles on osteoporosis in men and on atopic dermatitis; a Clinical Problem-Solving article describin ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 13.

This summary covers the issue of March 27, 2008. Featured are articles on diaphragm disuse atrophy and mechanical ventilation, coronary calcium as a predictor of coronary events across four racial or ethnic groups, cervical length at mid-pregnancy and risk of cesarean delivery, drug-review deadlines and safety problems, and cardiac connections and preventing arrhythmia; review articles on hydroxurea for the treatment of sickle cell anemia and on cardiac plasticity; a case report of a girl ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 12.

This summary covers the issue of March 20, 2008. Featured are articles on the treatment of the hypereosinophilic syndrome with mepolizumab, duration of red-cell storage and complications after cardiac surgery, polymorphisms associated with cholesterol and risk of cardiovascular events, and quality of life and satisfaction with outcome among prostate-cancer survivors; review articles on hormonal contraception in women of older reproductive age and on acinetobacter infection; a case report o ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 11.

This summary covers the issue of March 13, 2008. Featured are articles on anesthesia awareness and the bispectral index, cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose, DNA methylation markers and early recurrence in stage I lung cancer, VEGF inhibition and renal thrombotic microangiopathy, smoking and mortality among adults in India, and chemical immunosuppression in islet transplantation; review articles on epigenetics in cancer and on EGFR antagonists i ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 10.

This summary covers the issue of March 6, 2008. Featured are articles on a new arenavirus in a cluster of fatal transplant-associated diseases, genetic determinants of response to warfarin during initial anticoagulation, a Parkinsonian syndrome in methcathinone users and the role of manganese, autoimmune polyendocrine syndrome type 1 and NALP5, and the coordination of care in the U.S. health care system; review articles on urinary stress incontinence in women and on acute pulmonary embolis ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 9.

This summary covers the issue of February 28, 2008. Featured are articles on vasopressin versus norepinephrine infusion in patients with septic shock, severe anemia in Malawian children, two new susceptibility loci for systemic lupus erythematosus, cumulative association of five genetic variants with prostate cancer, and curing sickle cell anemia in a mouse model; review articles on phototherapy for neonatal jaundice and on systemic lupus erythematosus; a case report of a girl with chest p ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 8.

This summary covers the issue of February 21, 2008. Featured are articles on aprotinin during coronary-artery bypass grafting and risk of death, the effect of aprotinin on outcome after coronary-artery bypass grafting, surgical versus nonsurgical treatment for lumbar spinal stenosis, hepatitis E virus and chronic hepatitis in organ-transplant recipients, and scientific and legal viability of follow-on protein drugs; a review article on lumbar spinal stenosis; a case report of a woman with ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 7.

This summary covers the issue of February 14, 2008. Featured are articles on an association between microdeletion and microduplication at 16p11.2 and autism, B-cell depletion with rituximab in relapsing-remitting multiple sclerosis, local delivery of paclitaxel to inhibit restenosis during angioplasty of the leg, nasal CPAP or intubation for very preterm infants, a GPR54-activating mutation in a patient with central precocious puberty, and structural genomic variation and personalized medi ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 6.

This summary covers the issue of February 7, 2008. Featured are articles on thrombus aspiration during primary percutaneous coronary intervention, HLA-B5701 screening for hypersensitivity to abacavir, the effect of a multifactorial intervention on mortality in type 2 diabetes, phenotype and course of Hutchinson-Gilford progeria syndrome, and neonatal diagnosis and treatment of Menkes disease; a review article on neurogenic orthostatic hypotension; a Clinical Problem-Solving article that as ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 5.

This summary covers the issue of January 31, 2008. Featured are articles on mild traumatic brain injury in U.S. soldiers returning from Iraq, endovascular vs. open repair of abdominal aortic aneurysms in the Medicare population, cardiovascular events during World Cup Soccer, violence-related mortality in Iraq, and understanding inflammatory bowel disease; review articles on endovascular repair of abdominal aortic aneurysms and on oncogenes and cancer; a case report of a pregnant woman with ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 4.

This summary covers the issue of January 24, 2008. Featured are articles on drug-eluting stents vs. coronary-artery bypass grafting in multivessel coronary disease, a comparison of bare-metal and drug-eluting stents for off-label indications, HLA-mismatched renal transplantation without maintenance immunosuppression, tolerance and chimerism after renal and hematopoietic-cell transplantation, chimerism and tolerance in a recipient of a deceased-donor liver transplant, cost sharing and mammo ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 3.

This summary covers the issue of January 17, 2008. Featured are articles on iron-overload–related disease in HFE hereditary hemochromatosis, a citywide protocol for primary PCI in ST-segment elevation myocardial infarction, etanercept for plaque psoriasis in children and adolescents, selective publication of antidepressant trials, rules for donations to tissue banks, and guiding aerosol deposition in the lung; a review article on avian influenza in humans; an interactive Clinical Decisio ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 2.

This summary covers the issue of January 10, 2008. Featured are articles on hydrocortisone for septic shock, intensive insulin therapy and pentastarch resuscitation in severe sepsis, sirolimus for angiomyolipoma in tuberous sclerosis or lymphangioleiomyomatosis, outcomes in athletes with marked ECG repolarization abnormalities, and an HIF2A mutation in familial erythrocytosis; a review article on the long-QT syndrome; a case report of a man with sudden onset of abdominal pain and hypotens ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 358, No. 1.

This summary covers the issue of January 3, 2008. Featured are articles on delayed time to defibrillation after in-hospital cardiac arrest; functional outcome after language mapping for glioma resection; platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis; capecitabine and oxaliplatin for advanced esophagogastric cancer; and B-cell identity; review articles on metformin for the treatment of the polycystic ovary syndrome and on major depressive disorder; a Clinical Probl ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 26.

This summary covers the issue of December 27, 2007. Featured are articles on catheter ablation for the prevention of defibrillator therapy; paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer; local dystrophin restoration with PRO051; COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps; and military-civilian collaboration in trauma care and the senior visiting surgeon program; a review article on localized prostate cancer; a ca ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 25.

This summary covers the issue of December 20, 2007. Featured are articles on breast cancer stromal cells with TP53 mutations and nodal metastases, TP53 mutations and survival in squamous-cell carcinoma of the head and neck, reduced exposure to calcineurin inhibitors in renal transplantation, telbivudine versus lamivudine in patients with chronic hepatitis B, outcomes of care by hospitalists, general internists, and family physicians, and small RNAs and large DNA viruses; a review article o ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 24.

This summary covers the issue of December 13, 2007. Featured are articles on dexamethasone in Vietnamese adolescents and adults with bacterial meningitis, corticosteroids for bacterial meningitis in adults in sub-Saharan Africa, outcomes 18 months after partial face transplantation, cardiac-resynchronization therapy in heart failure with narrow QRS complexes, and rapid expansion of the health workforce in response to the HIV epidemic; review articles on erectile dysfunction and on platelet ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 23.

This summary covers the issue of December 6, 2007. Featured are articles on childhood body-mass index and the risk of coronary heart disease in adulthood, air quality and attenuated age-related decline in lung function, respiratory effects of exposure to diesel traffic in persons with asthma, metabolic effects of tesamorelin in patients with HIV, adolescent overweight and future adult coronary heart disease, and molecules that mediate mood; a review article on cochlear implants for childre ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 22.

This summary covers the issue of November 29, 2007. Featured are articles on eltrombopag for thrombocytopenia in cirrhosis associated with hepatitis C, eltrombopag and chronic idiopathic thrombocytopenic purpura, rosuvastatin in older patients with systolic heart failure, and patent foramen ovale and cryptogenic stroke in older patients; review articles on late-life depression and on CT scans and radiation exposure; a case report of a man with left ventricular dysfunction after heart trans ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 21.

This summary covers the issue of November 22, 2007. Featured are articles on torcetrapib in patients at high risk for coronary events, lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma, lung transplantation and survival in children with cystic fibrosis, the reporting of subgroup analyses in clinical trials, and the liver X receptor and atherosclerosis; a review article on sarcoidosis; a case report of a woman with rash, fever, and hypotension; and Perspective arti ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 20.

This summary covers the issue of November 15, 2007. Featured are articles on prasugrel vs. clopidogrel in acute coronary syndromes, a chitinase-like protein in the lung and circulation in patients with severe asthma, teriparatide or alendronate in glucocorticoid-induced osteoporosis, cetuximab for the treatment of colorectal cancer, and the anatomy of medical school patenting; a review article on diverticulitis; a case report of a man with inflammatory bowel disease and recent onset of fev ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 19.

This summary covers the issue of November 8, 2007. Featured are articles on the long-term effects of caffeine for apnea of prematurity, duration of humoral immunity to common viral and vaccine antigens, chemotherapy plus involved-field radiation in early-stage Hodgkin's disease, abnormal brain development in newborns with congenital heart disease, and hepatocellular carcinoma and sex; review articles on electroconvulsive therapy for depression and on chronic lung disease after premature bi ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 18.

This summary covers the issue of November 1, 2007. Featured are articles on zoledronic acid in reducing mortality after hip fracture, adjuvant chemotherapy for gastric cancer with S-1, incidental findings on brain MRI in the general population, and visualizing out-of-body experience in the brain; review articles on the assessment of patients' competence to consent to treatment and on leukotrienes; a Clinical Problem-Solving article describing a condition that is no respecter of age; and Pe ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 17.

This summary covers the issue of October 25, 2007. Featured are articles on hepatitis A vaccine versus immune globulin for postexposure prophylaxis; cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer; addition of insulin to oral therapy in type 2 diabetes; and reversing scarring in the heart; a review article on celiac disease; a case report of an HIV-positive man with anemia; an interactive Clinical Decisions featuring the management of stable coronary disease; an ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 16.

This summary covers the issue of October 18, 2007. Featured are articles on HPV DNA and Pap tests to screen for cervical cancer, early treatment with prednisolone or acyclovir in Bell's palsy, and STAT3 mutations in the hyper-IgE syndrome; review articles on hair loss in women and on the time to treatment in primary percutaneous coronary intervention; a case report of a woman with a second breast cancer; and Perspective articles on Medicare's new reimbursement rule and on "payment by resul ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 15.

This summary covers the issue of October 11, 2007. Featured are articles on a long-term follow-up of the West of Scotland Coronary Prevention Study, airway bacteria in neonates and childhood asthma, HER2 expression and response to paclitaxel in node-positive breast cancer, cardiomyopathy and exercise intolerance in muscle glycogen storage disease 0, quality of ambulatory care delivered to children in the United States, and myocardial repair and periostin; a review article on ursodeoxycholi ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 14.

This summary covers the issue of October 4, 2007. Featured are articles on the effectiveness of influenza vaccination in the community-dwelling elderly, donepezil for the treatment of agitation in Alzheimer's disease, effectiveness and safety of drug-eluting stents, and CT colonography versus colonoscopy for the detection of advanced neoplasia; review articles on osteoarthritis of the hip and on a critical appraisal of "chronic lyme disease"; a Clinical Problem-Solving article describing n ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 13.

This summary covers the issue of September 27, 2007. Featured are articles on early thimerosal exposure and neuropsychological outcomes at 7 to 10 years, antibodies against MICA antigens and kidney-transplant rejection, cardiovascular events and very low levels of LDL cholesterol, evidence of MEN-2 in the original description of classic pheochromocytoma, viral latency and the immune response, and on harnessing the power of default options to improve health care; a review article on uremia; ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 12.

This summary covers the issue of September 20, 2007. Featured are articles on long-term outcomes after repeat doses of antenatal corticosteroids, TRAF1-C5 as a risk locus for rheumatoid arthritis, a polymorphism in the CTGF promoter region associated with systemic sclerosis, and improving the health of the American people; a review article on gynecomastia; a case report of man with gastric cancer and lung nodules; and Perspective articles on health care for all and on a eulogy for a qualit ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 11.

This summary covers the issue of September 13, 2007. Featured are articles on diesel-exhaust inhalation in men with coronary disease, high-dose melphalan versus melphalan plus dexamethasone for AL amyloidosis, idraparinux versus standard therapy for venous thromboembolic disease, extended prophylaxis of venous thromboembolism with idraparinux, and prions, proteasomes, and mad cows; review articles on low-tidal-volume ventilation in ARDS and on myocardial reperfusion injury; a case report o ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 10.

This summary covers the issue of September 6, 2007. Featured are articles on epoetin alfa in critically ill patients, STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus, dronedarone for the maintenance of sinus rhythm in atrial fibrillation or flutter, minimizing ventricular pacing to reduce atrial fibrillation in sinus-node disease, and sustaining the engine of U.S. biomedical discovery; review articles on hypertriglyceridemia and on the control of neglected tropic ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 9.

This summary covers the issue of August 30, 2007. Featured are articles on risk alleles for multiple sclerosis identified by a genomewide study, reversal of idiopathic hypogonadotropic hypogonadism, saline or albumin for fluid resuscitation in traumatic brain injury, use of a continuous-flow device in patients awaiting heart transplantation, luteinizing hormone beta mutation and hypogonadism, and a tale about tau; a review article on the mechanisms of anabolic therapies for osteoporosis; a ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 8.

This summary covers the issue of August 23, 2007. Featured are articles on the effects of bariatric surgery on mortality in Sweden, long-term mortality after gastric bypass surgery, a study of sexuality and health among older U.S. adults, a genomewide analysis of sporadic amyotrophic lateral sclerosis; review articles on isolated systolic hypertension in the elderly and on normotensive ischemic acute renal failure; a case report of a man with recurrent fevers; and Perspective articles on h ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 7.

This summary covers the issue of August 16, 2007. Featured are articles on a genetic risk factor for periodic limb movements in sleep, medical abortion and the risk of subsequent pregnancy outcomes, sonification of removed hip and knee prostheses for the diagnosis of infection, prophylactic cranial irradiation in extensive small-cell lung cancer, a decade of direct-to-consumer prescription-drug advertising, and adherent invasive E. coli and Crohn's disease; a review article on psoralen and ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 6.

This summary covers the issue of August 9, 2007. Featured are articles on prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia, rituximab for the treatment of severe pemphigus, complement C3 variant and age-related macular degeneration, NXY-059 for acute ischemic stroke, and the tension between needing to improve care and knowing how to do it; review articles on acute ischemic stroke and on drug-induced immune thrombocytopenia; a case report of a pr ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 5.

This summary covers the issue of August 2, 2007. Featured are articles on genomewide association analysis of coronary artery disease, progesterone for the prevention of preterm delivery of twins, progesterone and preterm delivery among women with a short cervix, prevalence of rheumatic heart disease in Asia and Africa, and changing the trajectory of cognitive decline; a review article on the prevention of preterm delivery; a Clinical Problem-Solving article describing a growing problem; an ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 4.

This summary covers the issue of July 26, 2007. Featured are articles on dexamethasone for bronchiolitis, high-dose chemotherapy and stem-cell rescue for metastatic germ-cell tumors, partial thrombosis of the false lumen in acute type B aortic dissection, rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer, the spread of obesity in a large social network, and cancer and the Constitution; a review article on MRSA skin and soft-tissue infections; a case rep ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 3.

This summary covers the issue of July 19, 2007. Featured are articles on oral anticoagulant and antiplatelet therapy and peripheral arterial disease, certolizumab pegol for the treatment of Crohn's disease, maintenance therapy with certolizumab pegol for Crohn's disease, trends in the use of intracytoplasmic sperm injection in the United States, and rational design of cancer-drug combinations; review articles on BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia and on vit ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 2.

This summary covers the issue of July 12, 2007. Featured are articles on clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations, peginterferon alfa-2a and ribavirin for 16 or 24 weeks in hepatitis C virus genotype 2 or 3, neural-tube defects and folic acid fortification in Canada, use of health services by previously uninsured Medicare beneficiaries, and primary care and pay for performance in England; a review article on the management of an inherited predisposition t ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 357, No. 1.

This summary covers the issue of July 4, 2007. Featured are articles on first-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects, needlestick injuries among surgeons in training, allogeneic bone marrow transplantation in mevalonic aciduria, and industry sponsors' obligations to their research subjects; review articles on arteriovenous malformations of the brain and on disclosing harmful medical errors to patients; a case report of a boy with a calcified ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 26.

This summary covers the issue of June 28, 2007. Featured are articles on first-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects, needlestick injuries among surgeons in training, allogeneic bone marrow transplantation in mevalonic aciduria, and industry sponsors' obligations to their research subjects; review articles on arteriovenous malformations of the brain and on disclosing harmful medical errors to patients; a case report of a boy with a calcified ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 25.

This summary covers the issue of June 21, 2007. Featured are articles on injectable paromomycin for visceral leishmaniasis in India, the clinical course and prognosis of smoldering (asymptomatic) multiple myeloma, estrogen therapy and coronary-artery calcification, the natural history of multiple sclerosis with childhood onset, entecavir inhibition of HIV-1 replication, and microRNAs and the failing heart; a review article on natalizumab for multiple sclerosis; a case report of a college s ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 24.

This summary covers the issue of June 14, 2007. Featured are articles on rosiglitazone and cardiovascular adverse events, anidulafungin versus fluconazole for invasive candidiasis, prophylactic fluconazole in preterm neonates, the relationship between number of medical conditions and quality of care, and health information technology coming to medicine; a review article on the follow-up of patients with early breast cancer; a case report of a man with early-stage prostate cancer; and persp ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 23.

This summary covers the issue of June 7, 2007. Featured are articles on eprodisate for the treatment of renal disease in AA amyloidosis; natural history and outcome in systemic AA amyloidosis; adjuvant mitotane for adrenocortical carcinoma; bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species; explaining the decrease in U.S. deaths from coronary disease, 1980-2000; and mediating inflammation in rheumatoid arthritis; a review article on local therapy and survi ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 22.

This summary covers the issue of May 31, 2007. Featured are articles on surgery versus prolonged conservative treatment for sciatica, surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis, temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma, and survival after treatment with phenylacetate and benzoate for urea-cycle disorders; review articles on osteopenia and on prevention and treatment of major blood loss; a case report of a woman with relap ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 21.

This summary covers the issue of May 24, 2007. Featured are articles on aspirin and the risk of colorectal cancer in relation to the expression of COX-2, Burch colposuspension versus fascial sling to reduce urinary stress incontinence, advanced life support for out-of-hospital respiratory distress, level and volume of neonatal intensive care and mortality among very-low-birth-weight infants, the Supreme Court and abortion rights, and tanning and p53; a review article on bariatric surgery f ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 20.

This summary covers the issue of May 17, 2007. Featured are articles on strategies for reducing treatment in mild persistent asthma, rescue use of beclomethasone and albuterol in mild asthma, and glucose regulation in young adults with very low birth weight; review articles on the syndrome of inappropriate antidiuresis and on evolving concepts on an HIV vaccine; a case report of a woman with asthma and cardiorespiratory arrest; an interactive Clinical Decisions article on the treatment of ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 19.

This summary covers the issue of May 10, 2007. Featured are articles on a quadrivalent vaccine against HPV to prevent high-grade cervical lesions, a quadrivalent vaccine against HPV to prevent anogenital diseases, a case-control study of HPV and oropharyngeal cancer, end-of-life practices in the Netherlands under the euthanasia act, and cancer regression by senescence; a review article on sodium and potassium in the pathogenesis of hypertension; a case report of a man with fever and pain a ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 18.

This summary covers the issue of May 3, 2007. Featured are articles on once-yearly zoledronic acid for postmenopausal osteoporosis, intracoronary streptokinase after primary percutaneous coronary intervention, age at surgery for undescended testis and risk of testicular cancer, long-term effect of diabetes and its treatment on cognitive function, and use of physician's services under Medicare's resource-based payments; a review article on superior vena cava syndrome with malignant causes; ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 17.

This summary covers the issue of April 26, 2007. Featured are articles on adjunctive antidepressant treatments for bipolar depression, class of antiretroviral drugs and the risk of myocardial infarction, a lethal defect of mitochondrial and peroxisomal fission, physician-industry relationships, and the many roads to vaccine immunity; a review article on continuous positive airway pressure for obstructive sleep apnea; a video showing orotracheal intubation; a case report of a woman with gy ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 16.

This summary covers the issue of April 19, 2007. Featured are articles on tranfusion strategies in pediatric intensive care units, the effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia, omeprazole before endoscopy in patients with gastrointestinal bleeding, targeted therapy for inherited GPI deficiency, and the decrease in breast-cancer incidence in 2003 in the United States; a review article on fecal incontinence in adults; a case report of a woman with re ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 15.

This summary covers the issue of April 12, 2007. Featured are articles on optimal medical therapy with or without PCI for stable coronary disease, interleukin-1-receptor antagonist in type 2 diabetes mellitus, radiotherapy for glioblastoma in the elderly, inactivated poliovirus vaccine in Cuba, and retinal progenitor cells; a review article on strategies for safer liver surgery and partial liver transplantation; a case report of a man with neck pain, weakness in the arms, and cranial-nerve ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 14.

This summary covers the issue of April 5, 2007. Featured are articles on computer-aided detection in screening mammography, invariant natural killer T cells in asthma and COPD, vitamins and perinatal outcomes among HIV-negative women in Tanzania, and mutations in VANGL1 associated with neural-tube defects; review articles on prophylaxis for thromboembolism in hospitalized medical patients and on viral hepatitis in HIV infection; a clinical problem-solving article on building a diagnosis f ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 13.

This summary covers the issue of March 29, 2007. Featured are articles on MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer, effect of torcetrapib on the progression of coronary atherosclerosis, telomerase mutations in familial idiopathic pulmonary fibrosis, bronchial thermoplasty in asthma, and new insights on idiopathic pulmonary fibrosis; review articles on the varicella-zoster vaccine for the prevention of herpes zoster and on the withdrawal of a ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 12.

This summary covers the issue of March 22, 2007. Featured are articles on emergency duties and deaths from heart disease among U.S. firefighters, NALP1 in vitiligo-associated multiple autoimmune disease, neurodevelopment and cognition in children after enterovirus 71 infection, and redarkening of laser-treated port-wine stains; a review article on intermittent claudication; a case report of a woman with pain and swelling of the legs; and Perspective articles on HIV in India, on revising Me ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 11.

This summary covers the issue of March 15, 2007. Featured are articles on weekend versus weekday admission and mortality from myocardial infarction, allografting as compared with autografting for newly diagnosed myeloma, loss of vaccine-induced immunity to varicella over time, care patterns in Medicare and implications for pay for performance, and structural variation in the human genome; a review article on the failing heart; a case report of a man with chest pain followed by cardiac arr ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 10.

This summary covers the issue of March 8, 2007. Featured are articles on a pooled analysis of data comparing sirolimus-eluting stents with bare-metal stents, safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents, long-term outcomes with drug-eluting stents versus bare-metal stents in Sweden, stent thrombosis in randomized clinical trials of drug-eluting stents, analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents, and the ethical challenges pos ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 9.

This summary covers the issue of March 1, 2007. Featured are articles on the safety and efficacy of a recombinant hepatitis E vaccine, vancomycin-induced immune thrombocytopenia, treatment of periodontitis and endothelial function, improving the management of chronic disease at community health centers, and leveraging the delivery of liposomes to tumors; a review article on amiodarone for atrial fibrillation; a clinical problem-solving article entitled "Into the Woods"; and Perspective art ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 8.

This summary covers the issue of February 22, 2007. Featured are articles on salmeterol and fluticasone propionate and survival in COPD, reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus, DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer, missense mutations in the BCS1L gene as a cause of the Bjornstad syndrome, and new models of clinical clerkships; review articles on diabetic gastroparesis and on coronary microvascular dysfunction; a case report of a ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 7.

This summary covers the issue of February 15, 2007. Featured are articles on pulsed corticosteroid therapy for primary treatment of Kawasaki disease, endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis, live attenuated versus inactivated influenza vaccine in infants and young children, inheritance of a cancer-associated MLH1 germ-line epimutation, Medicaid revisited, and a closer look at follicular lymphoma; a review article on perioperative stroke; a case re ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 6.

This summary covers the issue of February 8, 2007. Featured are articles on clomiphene, metformin, or both for infertility in the polycystic ovary syndrome; GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis; interleukin-12/23 monoclonal antibody for the treatment of psoriasis; religion, conscience, and controversial clinical practices; and the regulatory and judicial oversight of nonprofit hospitals; a review article on the incidentally discovered adrenal m ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 5.

his summary covers the issue of February 1, 2007. Featured are articles on air pollution and cardiovascular events in women, new JAK2 mutations in polycythemia vera and idiopathic erythrocytosis, a communication strategy and brochure for relatives of patients dying in the ICU, prepubertal gynecomastia and lavender and tea tree oils, public reporting and pay for performance in hospital quality improvement, and a link between proposed mechanisms of Huntington's disease; a review article on i ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 4.

This summary covers the issue of January 25, 2007. Featured are articles on posaconazole or fluconazole in graft-versus-host disease, posaconazole versus fluconazole or itraconazole prophylaxis in patients with neutropenia, uterine-artery embolization versus surgery for symptomatic fibroids, lack of association between antimyelin antibodies and progression to multiple sclerosis; review articles on in vitro fertilization and on assessment in medical education; a case report of a boy with re ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 3.

This summary covers the issue of January 18, 2007. Featured are articles on a gene signature and outcome in breast cancer and other cancers, mammographic density and the risk of breast cancer, prevalence and effects of mutations in the leptin-receptor gene, tympanostomy tubes and developmental outcomes at 9 to 11 years of age, and wound healing with electric potential; review articles on international aeromedical evacuation and on partuition; a case report of a woman with a pigmented lesi ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 2.

This summary covers the issue of January 11, 2007. Featured are articles on sunitinib versus interferon alfa in metastatic renal-cell carcinoma, sorafenib in advanced clear-cell renal-cell carcinoma, response to antiretroviral therapy after one peripartum dose of nevirapine, inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia, and the risk of death for former prison inmates; a review article on concussion; a case report of a woman with epistaxis, hemate ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 356, No. 1.

This summary covers the issue of January 4, 2007. Featured are articles on a five-gene signature and survival in non-small-cell lung cancer, multidrug-resistant Salmonella enterica serotype Typhimurium associated with pet rodents, dopamine agonists and the risk of cardiac-valve regurgitation, valvular heart disease during treatment with dopamine agonists; review articles on primary PCI for myocardial infarction with ST-segment elevation and on Whipple's disease; a clinical problem-solving ...

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NEJM Audio Summary: Supplement to the New England Journal of Medicine, Vol. 355, No. 26.

This summary covers the issue of December 28, 2006. Featured are articles on decreasing catheter-related bloodstream infections in the ICU, lapatinib plus capecitabine for HER2-positive advanced breast cancer, female predominance and transmission distortion in the long-QT syndrome, T. evansi infection in humans, and deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta; a review article on monoclonal gammopathy of undetermined significance; a case report of ...

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