Link to the Show / Show Notes This summary covers the issue of January 3, 2008. Featured are articles on delayed time to defibrillation after in-hospital cardiac arrest; functional outcome after language mapping for glioma resection; platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis; capecitabine and oxaliplatin for advanced esophagogastric cancer; and B-cell identity; review articles on metformin for the treatment of the polycystic ovary syndrome and on major depressive disorder; a Clinical Problem-Solving article describing a failure to respond; and Perspective articles on implications for patient care during disasters and on efforts to localize higher brain functions.